Construction, Expression, and Characterization of a Recombinant Immunotoxin Targeting EpCAM
Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein overexpressed in human epithelioma but with relatively low expression in Oven Control PCB normal epithelial tissues.To exploit this differential expression pattern for targeted cancer therapy, an EpCAM-targeted immunotoxin was developed and its antitumor activity was i